System xc- pharmacology and its role in beta-L-ODAP pathology and glutathione synthesis

..................................................................................................................................ii List of Tables..................................................................................................................ûv Listof Rgures................................................................................................................... v Acknowledgments.......................................................................................................... vii Chapter 1: Background and Introduction.........................................................................1 Chapter 2: Methods and Materials..................................................................................17 Chapter 3: Differentiation of Substrate and Non-Substrate Inhibitors of Transport System : an Obligate Exchanger of L-Glutamate and L-Cysdne.......................... 23 Chapter 4: The LztAyrwj Excitotoxin P-NTOxalyl-L-a,P-Diaminopropionic Acid (P-LODAP) is an Effective Substrate of the L-Glutamate/L-Cystine Exchanger iSystemXc .................................................................................................. 38 Chapter 5: Evaluating the Relationship Between System Xc Activity and Maintenance of GSH Levels in Human Glioma Cells.................................53 Chapter6: Conclusions.............. 74 Bibliography..................................................................................................................78